Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.

Authors :: Bennani FE
Doudach L
Cherrah Y
Ramli Y
Karrouchi K
Ansar M
Faouzi MEA
Source :: Bioorganic chemistry [Bioorg Chem] 2020 Apr; Vol. 97, pp. 103470. Date of Electronic Publication: 2019 Dec 14.
Publication Year :: 2020
Abstract: Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C <subscript>3</subscript> H <subscript>3</subscript> N <subscript>2</subscript> H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Antineoplastic Agents chemical synthesis
Cell Line, Tumor
Chemistry Techniques, Synthetic
Drug Design
Drug Discovery
Drug Screening Assays, Antitumor
Humans
Neoplasms pathology
Pyrazoles chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Neoplasms drug therapy
Pyrazoles chemistry
Pyrazoles pharmacology

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