Back to Search Start Over

Stereotatic radiotherapy in metastatic non-small cell lung cancer: Combining immunotherapy and radiotherapy with a focus on liver metastases.

Authors :
Corrao G
Marvaso G
Ferrara R
Lo Russo G
Gugliandolo SG
Piperno G
Spaggiari L
De Marinis F
Orecchia R
Garassino MC
Jereczek-Fossa BA
Source :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2020 Apr; Vol. 142, pp. 70-79. Date of Electronic Publication: 2020 Feb 25.
Publication Year :
2020

Abstract

Presence of liver metastases correlates with worse survival and response to any treatments. This may be due to the microenvironment of liver which leads tumor to escape from Immune System. Stereotactic Body Radiation Therapy may help to sensitize Immune System and to improve the immunotherapy effect. Interest is being directed toward combining Immune-Checkpoint Inhibitors with radiotherapy to improve response to immunotherapy. However, the mechanisms by which radiation induces anti-tumor T-cells remain unclear. Preclinical studies founded radiotherapy enhances antitumor immune responses, increasing tumor antigen release, and inducing T-cell infiltration. Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. Nevertheless, how to optimally deliver combination therapy regarding dose-fractionation and timing of radiotherapy is unknown. The aim of this review is to explore the role of Stereotactic Body Radiation Therapy in metastatic non-small cell lung cancer, focusing on patients with liver metastases, and the possible immunological implications combining immunotherapy and radiotherapy.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-8332
Volume :
142
Database :
MEDLINE
Journal :
Lung cancer (Amsterdam, Netherlands)
Publication Type :
Academic Journal
Accession number :
32120227
Full Text :
https://doi.org/10.1016/j.lungcan.2020.02.017