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Acute chemotherapy-induced peripheral neuropathy due to oxaliplatin administration without cold stimulation.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Nov; Vol. 28 (11), pp. 5405-5410. Date of Electronic Publication: 2020 Mar 06. - Publication Year :
- 2020
-
Abstract
- Purpose: The incidence and time of onset of acute chemotherapy-induced peripheral neuropathy (ACIPN) caused by oxaliplatin remain unclarified. Hence, we investigated the prevalence, onset time, and location of ACIPN symptoms in patients with colorectal cancer (CRC) receiving oxaliplatin without cold stimulation.<br />Methods: The study cohort comprised patients receiving oxaliplatin for CRC at our hospital between April 2017 and August 2018. Patients were instructed not to touch and/or drink cold things and were monitored for ACIPN symptoms in the hospital for 24 h after chemotherapy. ACIPN symptoms that appeared > 24 h after chemotherapy were recorded at the next visit. Symptom appearance time was defined as the duration from the administration of chemotherapy until the appearance of paresthesia classified as grade 1 using the Common Terminology Criteria for Adverse Events.<br />Results: Forty-five patients received chemotherapy, comprising 23 men and 22 women, aged 67 years (29-88 years). The location of ACIPN was the fingers in 55.6% of cases, pharynx in 26.7%, perioral region in 24.4%, and feet in 6.7%. The average duration from oxaliplatin administration to symptom development was 182 min (range 62-443 min) for the fingers, 291 min (176-432 min) for the pharynx, 311 min (127-494 min) for the perioral region, and 297 min (234-355 min) for the feet. Pharyngeal symptoms were more common in patients older than 65 years than in those younger than 65 years.<br />Conclusions: The incidence and time of the onset of ACIPN caused by oxaliplatin varies between the body and regions.
- Subjects :
- Acute Disease
Adult
Aged
Aged, 80 and over
Cold Temperature adverse effects
Colorectal Neoplasms drug therapy
Colorectal Neoplasms epidemiology
Female
Humans
Incidence
Male
Middle Aged
Oxaliplatin administration & dosage
Paresthesia chemically induced
Paresthesia epidemiology
Physical Stimulation adverse effects
Prevalence
Time Factors
Antineoplastic Combined Chemotherapy Protocols adverse effects
Oxaliplatin adverse effects
Peripheral Nervous System Diseases chemically induced
Peripheral Nervous System Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1433-7339
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32144582
- Full Text :
- https://doi.org/10.1007/s00520-020-05387-z