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Management of residual disease after chemotherapy in germ cell tumors.
- Source :
-
Current opinion in oncology [Curr Opin Oncol] 2020 May; Vol. 32 (3), pp. 250-255. - Publication Year :
- 2020
-
Abstract
- Purpose of Review: Although testicular cancer remains a highly curable malignancy, challenges and uncertainty still remain in certain aspects of management. Residual disease after chemotherapy in patients with germ cell tumors (GCT) remains one of these challenges. We aim to highlight the recent literature on the management of residual disease after chemotherapy in GCT and the emerging innovations that may provide further guidance into this area.<br />Recent Findings: A subset of patients with GCT will have residual disease after chemotherapy, and management of these patients involves highly skilled multidisciplinary experts including medical oncologists, surgeons, radiologists, and pathologists. Management options depend on histologic subtype, either seminoma or nonseminoma, and involve size criteria, possible further imaging modalities, and tumor markers. Even with these tools at highly specialized expert centers, uncertainty in management remains, and recent literature has explored the use of newer biomarkers to aid in these cases.<br />Summary: Postchemotherapy residual masses in GCT can prove to be complicated cases to manage. Balancing survival with quality of life outcomes is important and requires a multidisciplinary team experienced in treating GCT.
- Subjects :
- Biomarkers, Tumor blood
Humans
Male
Neoplasm, Residual blood
Neoplasm, Residual pathology
Neoplasm, Residual surgery
Neoplasms, Germ Cell and Embryonal blood
Neoplasms, Germ Cell and Embryonal surgery
Seminoma blood
Seminoma drug therapy
Seminoma pathology
Seminoma surgery
Testicular Neoplasms blood
Testicular Neoplasms surgery
Neoplasms, Germ Cell and Embryonal drug therapy
Neoplasms, Germ Cell and Embryonal pathology
Testicular Neoplasms drug therapy
Testicular Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-703X
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32168037
- Full Text :
- https://doi.org/10.1097/CCO.0000000000000619