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Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2020 Feb 04; Vol. 17 (4), pp. 490-497. Date of Electronic Publication: 2020 Feb 04 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 ( MACC1 ) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 MACC1 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these MACC1 SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in MACC1 SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG ( p =0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate ( p =0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Adult
Aged
Asian People
Female
Genetic Predisposition to Disease genetics
Genotype
Humans
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide genetics
Retrospective Studies
Survival Rate
Taiwan
Uterine Cervical Neoplasms mortality
Trans-Activators genetics
Uterine Cervical Neoplasms genetics
Uterine Cervical Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32174779
- Full Text :
- https://doi.org/10.7150/ijms.40204