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(-)-Epigallocatechin-3-gallate (EGCG) attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats.
- Source :
-
Scientific reports [Sci Rep] 2020 Mar 16; Vol. 10 (1), pp. 4783. Date of Electronic Publication: 2020 Mar 16. - Publication Year :
- 2020
-
Abstract
- Epigallocatechin-3-gallate (EGCG), a main active catechin in green tea, was reported to attenuate renal injury and hypertension. However, its effects on salt-induced hypertension and renal injury remain unclear. In the present study, we explored its effects on hypertension and renal damage in Dahl rats with salt-sensitive hypertension. We found that EGCG could lower blood pressure after 6 weeks of oral administration, reduce 24 h urine protein levels and decrease creatinine clearance, and attenuate renal fibrosis, indicating that it could attenuate hypertension by protecting against renal damage. Furthermore, we studied the renal protective mechanisms of EGCG, revealing that it could lower malondialdehyde levels, reduce the numbers of infiltrated macrophages and T cells, and induce the apoptosis of NRK-49F cells. Considering that the 67 kD laminin receptor (67LR) binds to EGCG, its role in EGCG-induced fibroblast apoptosis was also investigated. The results showed that an anti-67LR antibody partially abrogated the apoptosis-inducing effects of EGCG on NRK-49F cells. In summary, EGCG may attenuate renal damage and salt-sensitive hypertension via exerting anti-oxidant, anti-inflammatory, and apoptosis-inducing effects on fibroblasts; the last effect is partially mediated by 67LR, suggesting that EGCG represents a potential strategy for treating salt-sensitive hypertension.
- Subjects :
- Administration, Oral
Animals
Apoptosis drug effects
Catechin administration & dosage
Catechin metabolism
Catechin pharmacology
Cells, Cultured
Disease Models, Animal
Fibroblasts pathology
Malondialdehyde metabolism
Rats
Rats, Inbred Dahl
Receptors, Laminin metabolism
Acute Kidney Injury drug therapy
Acute Kidney Injury etiology
Catechin analogs & derivatives
Hypertension drug therapy
Hypertension etiology
Phytotherapy
Sodium Chloride, Dietary adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32179848
- Full Text :
- https://doi.org/10.1038/s41598-020-61794-6