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Liver stiffness measured by MR elastography is a predictor of early HCC recurrence after treatment.
- Source :
-
European radiology [Eur Radiol] 2020 Aug; Vol. 30 (8), pp. 4182-4192. Date of Electronic Publication: 2020 Mar 18. - Publication Year :
- 2020
-
Abstract
- Objectives: Magnetic resonance elastography (MRE) is a non-invasive tool for measuring liver stiffness (LS) with high diagnostic accuracy. This study investigated whether quantified LS by MRE could predict early recurrence of patients with hepatocellular carcinoma (HCC) within the Milan criteria.<br />Methods: A prospectively collected cohort, which included the HCC patients who underwent MRE before treatment (an HCC-MRE cohort), was analyzed. In the HCC-MRE cohort, only patients under the Milan criteria, who underwent hepatic resection, radiofrequency ablation (RFA), or transarterial chemoembolization (TACE), were reviewed. We investigated whether LS assessed by MRE was an independent predictor of early recurrence using Cox regressions and Kaplan-Meier analyses.<br />Results: A total of 192 HCC patients under the Milan criteria who underwent hepatic resection (n = 96), RFA (n = 23), or TACE (n = 73) were included. Higher LS ratings (kPa; hazard ratio [HR] = 1.12; 95% confidence interval [CI] = 1.01-1.25; p = 0.040) emerged as an independent risk factor for early tumor recurrence. In the subgroup analysis, higher LS ratings were associated with higher risks of early HCC recurrence in both the resection/RFA group (> 4.5 kPa; HR = 2.95; 95% CI = 1.26-6.94; p = 0.013) and the TACE group (> 6 kPa; HR = 2.94; 95% CI = 1.27-6.83; p = 0.012).<br />Conclusion: LS assessed by MRE was an independent predictor of early recurrence among HCC patients under the Milan criteria after achieving a complete response.<br />Key Points: • Liver parenchymal stiffness measured by MRE predicts early recurrence of treated HCC under Milan criteria. • A liver stiffness > 5.5 kPa was associated with worse recurrence-free survival. • Patients with high pre-treatment LS may benefit from stringent follow-up.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular surgery
Catheter Ablation
Chemoembolization, Therapeutic adverse effects
Female
Hepatectomy
Humans
Kaplan-Meier Estimate
Liver Neoplasms pathology
Liver Neoplasms surgery
Male
Middle Aged
Proportional Hazards Models
Retrospective Studies
Risk Factors
Treatment Outcome
Carcinoma, Hepatocellular diagnostic imaging
Elasticity Imaging Techniques
Liver Neoplasms diagnostic imaging
Neoplasm Recurrence, Local diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 32189053
- Full Text :
- https://doi.org/10.1007/s00330-020-06792-y