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Greater activation of the response inhibition network in females compared to males during stop signal task performance.

Authors :
Gaillard A
Rossell SL
Carruthers SP
Sumner PJ
Michie PT
Woods W
Neill E
Phillipou A
Toh WL
Hughes ME
Source :
Behavioural brain research [Behav Brain Res] 2020 May 27; Vol. 386, pp. 112586. Date of Electronic Publication: 2020 Mar 16.
Publication Year :
2020

Abstract

Previous neuroimaging studies have reported differences in regional brain activation between males and females during stop signal task performance, suggesting the presence of sex-linked differences in brain network organization of inhibitory ability. Despite a growing literature on sex differences during stop signal task performance, a consensus still has not been reached due to variations in task design and analysis methods. Due to these disparate findings we used up to date stop signal task methods to compare behavioral performance and associated brain activation between males and females using an event-related functional magnetic resonance imaging design. We observed that males were faster in inhibiting their responses, but females exhibited marked increased in stopping network activation, in addition to increased activation of the anterior insula and left amygdala. These findings suggest that males and females process stop signals differently.<br />Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7549
Volume :
386
Database :
MEDLINE
Journal :
Behavioural brain research
Publication Type :
Academic Journal
Accession number :
32194187
Full Text :
https://doi.org/10.1016/j.bbr.2020.112586