A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides.

Authors :: Liu W
Leischner T
Li W
Junge K
Beller M
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jul 06; Vol. 59 (28), pp. 11321-11324. Date of Electronic Publication: 2020 May 11.
Publication Year :: 2020
Abstract: A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf) <subscript>2</subscript> as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields.<br /> (© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

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