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Ceftobiprole: a potential empirical post-operative monotherapy in prosthetic joint infections.
- Source :
-
Annals of clinical microbiology and antimicrobials [Ann Clin Microbiol Antimicrob] 2020 Mar 21; Vol. 19 (1), pp. 9. Date of Electronic Publication: 2020 Mar 21. - Publication Year :
- 2020
-
Abstract
- Background: This study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative empirical antibiotic therapy (PEAT) (vancomycin with either cefepime, third-generation cephalosporin or piperacillin-tazobactam).<br />Methods: We performed a 1-year retrospective study on all the surgical procedures performed in our hospital for PJI. Susceptibility profiles of all the strains cultured from surgical samples were reviewed to compare ceftobiprole to current used associations.<br />Results: During the study period (from January 2018 to December 2018), we identified 106 patients managed for PJI and a total of 216 surgical interventions. One hundred-fifty strains were identified from intraoperative samples, excluding redundant strains. Staphylococcus spp. represented 52.7% of all strains and Enterobacteriales 13.3%. Twenty-three patients had polymicrobial infection (22%). Among 149 surgical procedures with positive culture results, ceftobiprole covered the bacterial strains in 138 (92.6%) cases. In comparison, this percentage was 94.6% for vancomycin plus cefepime (p = 0.64), 92.6% for vancomycin plus a third-generation cephalosporin in 138 cases (p = 1) and 94.6% for vancomycin plus piperacillin-tazobactam) (p = 0.64).<br />Conclusion: Based on antimicrobial susceptibility testing, our results suggest that ceftobiprole could be an interesting option for PEAT in PJIs, allowing the use of a single agent.
- Subjects :
- Coinfection drug therapy
Enterobacteriaceae Infections drug therapy
Female
Humans
Male
Microbial Sensitivity Tests
Prosthesis-Related Infections microbiology
Retrospective Studies
Staphylococcal Infections drug therapy
Staphylococcal Infections microbiology
Anti-Bacterial Agents therapeutic use
Cephalosporins therapeutic use
Prosthesis-Related Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1476-0711
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of clinical microbiology and antimicrobials
- Publication Type :
- Academic Journal
- Accession number :
- 32199450
- Full Text :
- https://doi.org/10.1186/s12941-020-00351-5