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Stable Fabrication of Zwitterionic Coating Based on Copper-Phenolic Networks on Contact Lens with Improved Surface Wettability and Broad-Spectrum Antimicrobial Activity.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Apr 08; Vol. 12 (14), pp. 16125-16136. Date of Electronic Publication: 2020 Mar 27. - Publication Year :
- 2020
-
Abstract
- Ocular dryness and contact lens(CL)-related microbial keratitis (MK) are two major risks of wearing CLs. The development of multifunctional surface coating for CLs with excellent hydrating and antimicrobial properties is a practical strategy to improve the comfort of CL wearers and to prevent corneal infection. Here, we develop zwitterionic and antimicrobial metal-phenolic networks (MPNs) based on the coordination of copper ions (Cu <superscript>II</superscript> ) and the poly(carboxylbetaine- co -dopamine methacrylamide) copolymer (PCBDA), which can be easily one-step prepared onto CLs due to the near-universal adherent properties of catechol groups. The zwitterionic and antifouling carboxybetaine (CB) groups of the Cu <superscript>II</superscript> -PCBDA coating can significantly increase the wettability of CLs and reduce their protein adsorptions, resulting in a lens surface that is more water retentive and with lower protein binding to prevent tear film evaporation and eye dryness. In addition, since the immobilized copper ions in the MPNs impart them with ion-mediated antimicrobial activity, the Cu <superscript>II</superscript> -PCBDA coating exhibits a strong and broad-spectrum antimicrobial activity against MK related pathogenic microbes, including bacteria, such as Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus , and fungi, such as Candida albicans . Compared with a pristine CL, the Cu <superscript>II</superscript> -PCBDA-coated CL effectively inhibited biofilm formation even after daily exposure to the above microbial environment for 14 days. Notably, the Cu <superscript>II</superscript> -PCBDA coating developed in this study is not only biocompatible with 100% cell viability following direct contact with human corneal epithelial cells (HCECs) for 48 h but also maintains the optical clarity of the native CLs. Thus, the Cu <superscript>II</superscript> -PCBDA coating has a great application potential for the development of a multifunctional surface coating for CLs for increased CL comfort and prevention of MK.
- Subjects :
- Adsorption drug effects
Anti-Infective Agents chemical synthesis
Anti-Infective Agents pharmacology
Bacterial Adhesion drug effects
Coated Materials, Biocompatible chemical synthesis
Coated Materials, Biocompatible pharmacology
Copper chemistry
Escherichia coli drug effects
Escherichia coli pathogenicity
Humans
Phenols chemistry
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa pathogenicity
Staphylococcus aureus drug effects
Staphylococcus aureus pathogenicity
Surface Properties
Anti-Infective Agents chemistry
Coated Materials, Biocompatible chemistry
Contact Lenses microbiology
Wettability drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 12
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 32202402
- Full Text :
- https://doi.org/10.1021/acsami.0c02143