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Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents.
- Source :
-
Chemistry, an Asian journal [Chem Asian J] 2020 May 15; Vol. 15 (10), pp. 1536-1539. Date of Electronic Publication: 2020 Apr 07. - Publication Year :
- 2020
-
Abstract
- A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.<br /> (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Cyclization
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Indoles chemical synthesis
Indoles chemistry
Molecular Conformation
Organoselenium Compounds chemical synthesis
Organoselenium Compounds chemistry
Spiro Compounds chemical synthesis
Spiro Compounds chemistry
Structure-Activity Relationship
Aldehydes chemistry
Antineoplastic Agents pharmacology
Indoles pharmacology
Light
Organoselenium Compounds pharmacology
Spiro Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1861-471X
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Chemistry, an Asian journal
- Publication Type :
- Academic Journal
- Accession number :
- 32207240
- Full Text :
- https://doi.org/10.1002/asia.202000298