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CD133 antibody targeted delivery of gold nanostars loading IR820 and docetaxel for multimodal imaging and near-infrared photodynamic/photothermal/chemotherapy against castration resistant prostate cancer.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2020 Jul; Vol. 27, pp. 102192. Date of Electronic Publication: 2020 Mar 27. - Publication Year :
- 2020
-
Abstract
- Due to the lack of effective strategies on the treatment of castration resistant prostate cancer (CRPC), we established a multifunctional nanoplatform (GNS@IR820/DTX-CD133) for the synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)/chemotherapy (CT) under the monitoring of multimodal near-infrared (NIR) fluorescence/photoacoustic (PA) imaging. Benefiting from the guided effect of CD133 antibody, GNS@IR820/DTX-CD133 can targetedly deliver the loaded drug to the tumor tissues, which can further contribute to the combined therapeutic effect. Our experimental results prove that the bio-distribution of GNS@IR820/DTX-CD133 can be monitored with NIR fluorescence and PA imaging. In addition, the application of GNS@IR820/DTX-CD133 for in vitro and in vivo therapy achieves the excellent antitumor effects of the synergistic PTT/PDT/CT strategies under the NIR-light irradiation. Therefore, as a multifunctional nanoplatform integrating the PTT/PDT/CT strategies with tumor multimodal imaging or drug tracing, GNS@IR820/DTX-CD133 has the great potential for clinical applications in the antitumor therapy of CRPC.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- AC133 Antigen chemistry
AC133 Antigen pharmacology
Animals
Cell Line, Tumor
Combined Modality Therapy
Disease Models, Animal
Docetaxel chemistry
Docetaxel pharmacology
Drug Delivery Systems
Gold chemistry
Gold pharmacology
Heterografts
Humans
Indocyanine Green analogs & derivatives
Indocyanine Green chemistry
Indocyanine Green pharmacology
Male
Mice
Molecular Targeted Therapy
Multimodal Imaging
Prostatic Neoplasms, Castration-Resistant genetics
Prostatic Neoplasms, Castration-Resistant pathology
AC133 Antigen genetics
Nanoparticles chemistry
Photochemotherapy
Photothermal Therapy
Prostatic Neoplasms, Castration-Resistant therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 27
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32229215
- Full Text :
- https://doi.org/10.1016/j.nano.2020.102192