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[Vascular Remodeling Induced by Biological Stresses].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2020; Vol. 140 (4), pp. 509-512. - Publication Year :
- 2020
-
Abstract
- The thymus is a vital organ for functional immune systems, and is the site of T cell development, which plays a central role in cellular immune defenses. Unlike other major organs, the thymus is highly dynamic in size and structure. It shrinks immediately upon bacterial infection, aging, pregnancy, mental stress, nutritional deficiency, and more. The reduction in size and function of the thymus during such biological events is called thymic involution or thymic atrophy; thymic involution is a particularly important issue because dysfunctional T cell immunity increases the risks of tumorigenesis and infectious diseases. However, the molecular mechanisms underlying thymic involution remain obscure. Our recent study indicated that blood vessels are remodeled during thymic involution that occurs upon aging, estradiol-treatment, or nutritional deficiency. We also found that prostanoid synthesis is induced during thymic involution. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or etodolac, at least partially inhibited thymic involution-induced remodeling of the blood vessels, suggesting that prostanoids are involved in blood vessel remodeling. Our results revealed the potential role of blood vessel remodeling during thymic involution, which can lead to biological stress-induced immunosenescence.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Humans
Mice
Prostaglandins metabolism
Prostaglandins physiology
Stress, Physiological physiology
T-Lymphocytes immunology
Thymus Gland pathology
Blood Vessels immunology
Blood Vessels physiopathology
Stress, Physiological immunology
Stress, Psychological immunology
Thymus Gland immunology
Vascular Remodeling drug effects
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1347-5231
- Volume :
- 140
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 32238633
- Full Text :
- https://doi.org/10.1248/yakushi.19-00221-1