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Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.
- Source :
-
Documenta ophthalmologica. Advances in ophthalmology [Doc Ophthalmol] 2020 Oct; Vol. 141 (2), pp. 195-204. Date of Electronic Publication: 2020 Apr 01. - Publication Year :
- 2020
-
Abstract
- Purpose: To report a patient with thymoma-associated retinopathy presenting as having a good visual prognosis.<br />Methods: Case report and literature review.<br />Case Report: A 42-year-old female patient was referred to our hospital for complaints of sudden visual-field defects bilaterally. Decimal corrected visual acuity (VA) was 1.5 and 1.2 in the right (RE) and left eyes (LE), respectively. Fundus autofluorescence revealed hyper-autofluorescence from the posterior pole to mid-peripheral retina in both eyes. Full-field electroretinography (ERG) amplitudes were reduced to 20-50% and 30-50% of our controls for the scotopic and photopic conditions, respectively. A systemic examination revealed the presence of thymoma, and the patient underwent thymectomy and immunosuppression therapies. Immunohistochemical analysis using the patient's serum showed immunolabeling on the photoreceptor inner segment and outer plexiform layer in the monkey retina. Two years later, VA remained at 1.5 and 1.2 in RE and LE. ERG amplitudes improved to 30-60% of the controls for the scotopic conditions. However, photopic ERG showed no remarkable change.<br />Conclusions: To our knowledge, improvement of reduced rod-mediated ERG responses has not been described in seven previously reported patients with thymoma-associated retinopathy. The good visual prognosis of our patient may be associated with well-timed intervention.
- Subjects :
- Adult
Combined Modality Therapy
Electroretinography
Female
Humans
Immunosuppressive Agents therapeutic use
Paraneoplastic Syndromes, Ocular diagnosis
Paraneoplastic Syndromes, Ocular therapy
Thymectomy
Thymoma diagnosis
Thymoma therapy
Thymus Neoplasms diagnosis
Thymus Neoplasms therapy
Tomography, Optical Coherence
Vision Disorders physiopathology
Visual Acuity physiology
Visual Fields physiology
Paraneoplastic Syndromes, Ocular physiopathology
Retinal Rod Photoreceptor Cells physiology
Thymoma physiopathology
Thymus Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2622
- Volume :
- 141
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Documenta ophthalmologica. Advances in ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 32239315
- Full Text :
- https://doi.org/10.1007/s10633-020-09764-1