Back to Search
Start Over
Perinatal events predicting retinopathy of prematurity in extremely pre-term infants.
Perinatal events predicting retinopathy of prematurity in extremely pre-term infants.
- Source :
-
Journal of neonatal-perinatal medicine [J Neonatal Perinatal Med] 2020; Vol. 13 (2), pp. 261-266. - Publication Year :
- 2020
-
Abstract
- Background: Extremely preterm infants are peculiar in regard to their risk of retinopathy of prematurity (ROP). In this study, we aim to study insults that may affect extremely preterm infants, including prenatal, at birth, and postnatal insults and their effect on the development of ROP.<br />Methods: This study used the data from Prematurity and Respiratory Outcomes Program (PROP). All included infants with a gestational age of 23 0/7 to 28 6/7 weeks using best obstetrical estimate. We included stressful events and/or modifiable variables that may affect the normal development. We used multiple regression analysis in our statistical analysis.<br />Results: We included a total of 751 infants in our study. The mean birth weight for the included sample was 915.1 (±232.94) grams. 391 (52.1%) Infants were diagnosed with ROP. We found a significant negative correlation between ROP development and birth weight (pā<ā0.001), with a correlation coefficient of - 0.374. We found that the need for prophylactic indomethacin (OR 1.67), the occurrence of air leaks (OR: 2.35), ventilator-associated pneumonia (OR: 2.01), isolated bowel perforations (OR: 3.7), blood culture-proven sepsis (OR: 1.5), other infections (OR: 1.44), and receiving ventricular shunt (OR: 2.9) are significantly associated with the development of ROP.<br />Conclusions: We believe this study included the largest number of factors studied in the largest sample of extremely premature infants. We recommend a screening program for extremely preterm infants that takes into account a scoring system with higher scores for complicated condition.
- Subjects :
- Birth Weight
Cellulitis epidemiology
Continuous Positive Airway Pressure statistics & numerical data
Ductus Arteriosus, Patent drug therapy
Ductus Arteriosus, Patent epidemiology
Embolism, Air epidemiology
Female
Humans
Infant, Extremely Low Birth Weight
Infant, Extremely Premature
Infant, Newborn
Infant, Very Low Birth Weight
Male
Mediastinal Emphysema epidemiology
Meningitis epidemiology
Pneumopericardium epidemiology
Pneumoperitoneum epidemiology
Pneumothorax epidemiology
Protective Factors
Subcutaneous Emphysema epidemiology
Urinary Tract Infections epidemiology
Cardiovascular Agents therapeutic use
Cerebrospinal Fluid Shunts statistics & numerical data
Indomethacin therapeutic use
Intestinal Perforation epidemiology
Neonatal Sepsis epidemiology
Pneumonia, Ventilator-Associated epidemiology
Retinopathy of Prematurity epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-4429
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neonatal-perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32250325
- Full Text :
- https://doi.org/10.3233/NPM-190336