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Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method.
- Source :
-
Journal of materials chemistry. B [J Mater Chem B] 2014 Nov 07; Vol. 2 (41), pp. 7141-7148. Date of Electronic Publication: 2014 Sep 17. - Publication Year :
- 2014
-
Abstract
- In this paper, we present a new and facile one-step method for the fabrication of a water-soluble graphene-phthalocyanine (GR-Pc) hybrid material by simply sonicating GR with a hydrophilic Pc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc). In the resultant hybrid material, TSCuPc is coated on the skeleton of pristine GR via non-covalently π-π interaction, detailedly characterized by UV-vis/Raman spectra, X-ray photoelectron spectroscopy (XPS), etc. The obtained GR-Pc hybrid (GR-TSCuPc) is applied for photothermal therapy (PTT) and photodynamic therapy (PDT). In this PTT/PDT system, both GR and TSCuPc operate as multifunctional agents: GR acts as a photosensitizer carrier and PTT agent, while TSCuPc acts as a hydrophilic PDT agent. Furthermore, the results of cell viability show that the phototherapy effect of GR-TSCuPc is observably higher than that of free TSCuPc, indicating that combined noninvasive PTT/PDT exhibits better anti-cancer efficacy in vitro. Such results highlight that this work provide a facile method to develop efficacious dual-modality carbon nanoplatform for developing cancer therapeutics.
Details
- Language :
- English
- ISSN :
- 2050-7518
- Volume :
- 2
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- Journal of materials chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 32261792
- Full Text :
- https://doi.org/10.1039/c4tb01038h