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Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane.
- Source :
-
Acta biomaterialia [Acta Biomater] 2020 Jun; Vol. 109, pp. 95-108. Date of Electronic Publication: 2020 Apr 06. - Publication Year :
- 2020
-
Abstract
- In order to elicit a desired barrier function in guided bone regeneration (GBR) or guided tissue regeneration (GTR), a barrier membrane has to maintain its integrity for a certain period of time to guarantee the regeneration of target tissue. Due to the complexity and variety of clinical conditions, the healing time required for tissue regeneration varies from one case to another, which implies the need for tailoring the barrier membranes to diverse conditions via manipulating their degradation property. As a "non-self" biomaterial, a barrier membrane will inevitably trigger host-membrane immune response after implantation, which entails the activation of phagocytic cells. In the degradation process of a barrier membrane, the cell-mediated degradation may play a more vital role than enzymatic and physicochemical dissolution; however, limited studies have been carried out on this topic. In this context, we investigated the cell-mediated degradation and illustrated the possible key cells and mediators for immunomodulation via in vivo and in vitro studies. We discovered that IL-13, a key cytokine mainly released by T helper 2 cells (Th2), induced the formation of foreign body giant cells (FBGCs), thus resulting in membrane degradation. Neutralizing IL-13 could suppress membrane degradation and formation of FBGC. The contributions of this study are (1) unveiling the immune mechanisms underlying the cell-mediated collagen membrane degradation; (2) allowing the formation of an "immunodegradation" strategy to develop an "immune-smart" barrier membrane to manipulate its degradation; (3) providing the key regulatory immune cells and cytokines for the immunomodulation target in collagen membrane degradation. STATEMENT OF SIGNIFICANCE: The significance of this research includes.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Absorbable Implants
Animals
Collagen chemistry
Collagen immunology
Giant Cells, Foreign-Body immunology
Giant Cells, Foreign-Body metabolism
Interleukin-13 antagonists & inhibitors
Leukocytes, Mononuclear immunology
Leukocytes, Mononuclear metabolism
Male
Rats, Wistar
Swine
Th2 Cells metabolism
Collagen metabolism
Immunity, Cellular drug effects
Immunologic Factors pharmacology
Interleukin-13 metabolism
Membranes, Artificial
Receptors, Interleukin-4, Type II metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-7568
- Volume :
- 109
- Database :
- MEDLINE
- Journal :
- Acta biomaterialia
- Publication Type :
- Academic Journal
- Accession number :
- 32268238
- Full Text :
- https://doi.org/10.1016/j.actbio.2020.03.038