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The role of inflammation in stress cardiomyopathy.

Authors :
Ciutac AM
Dawson D
Source :
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2021 May; Vol. 31 (4), pp. 225-230. Date of Electronic Publication: 2020 Mar 20.
Publication Year :
2021

Abstract

Stress cardiomyopathy (SC) is an increasingly recognized form of acute heart failure, which has been linked to a wide variety of emotional and physical triggers. The pathophysiological mechanisms of the disease remain incompletely understood, however, inflammation has been recently shown to play a pivotal role. This review summarizes the most notable findings of myocardial inflammation, demonstrated from biopsies and cardiac magnetic resonance imaging in humans. In the acute stage macrophage infiltration appears to represent the substrate for myocardial edema, together defining the local myocardial inflammation. This appears to evolve into a low grade systemic chronic inflammation which could explain the protracted clinical course of these patients and raises hope for finding a specific SC cardiac biomarker as well as a therapeutic breakthrough. As a parallel to the human findings the review covers some of the emerging mechanistic insights from experimental models, which, albeit not proven in the human condition, highlight the possible importance in pursuing distinct paths of investigation such as the beta-receptor signaling, aberrations of nitric oxide generation and signaling and the contribution of the vascular endothelium/permeability to edema and inflammation during the acute stage.<br /> (Copyright © 2020. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1873-2615
Volume :
31
Issue :
4
Database :
MEDLINE
Journal :
Trends in cardiovascular medicine
Publication Type :
Academic Journal
Accession number :
32276825
Full Text :
https://doi.org/10.1016/j.tcm.2020.03.005