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The role of inflammation in stress cardiomyopathy.
- Source :
-
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2021 May; Vol. 31 (4), pp. 225-230. Date of Electronic Publication: 2020 Mar 20. - Publication Year :
- 2021
-
Abstract
- Stress cardiomyopathy (SC) is an increasingly recognized form of acute heart failure, which has been linked to a wide variety of emotional and physical triggers. The pathophysiological mechanisms of the disease remain incompletely understood, however, inflammation has been recently shown to play a pivotal role. This review summarizes the most notable findings of myocardial inflammation, demonstrated from biopsies and cardiac magnetic resonance imaging in humans. In the acute stage macrophage infiltration appears to represent the substrate for myocardial edema, together defining the local myocardial inflammation. This appears to evolve into a low grade systemic chronic inflammation which could explain the protracted clinical course of these patients and raises hope for finding a specific SC cardiac biomarker as well as a therapeutic breakthrough. As a parallel to the human findings the review covers some of the emerging mechanistic insights from experimental models, which, albeit not proven in the human condition, highlight the possible importance in pursuing distinct paths of investigation such as the beta-receptor signaling, aberrations of nitric oxide generation and signaling and the contribution of the vascular endothelium/permeability to edema and inflammation during the acute stage.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Animals
Biopsy
Humans
Inflammation Mediators metabolism
Magnetic Resonance Imaging
Myocardium metabolism
Myocardium pathology
Signal Transduction
Edema, Cardiac diagnostic imaging
Edema, Cardiac metabolism
Edema, Cardiac pathology
Edema, Cardiac physiopathology
Myocarditis diagnostic imaging
Myocarditis metabolism
Myocarditis pathology
Myocarditis physiopathology
Takotsubo Cardiomyopathy diagnostic imaging
Takotsubo Cardiomyopathy metabolism
Takotsubo Cardiomyopathy pathology
Takotsubo Cardiomyopathy physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2615
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32276825
- Full Text :
- https://doi.org/10.1016/j.tcm.2020.03.005