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Roles of Autophagy and Pancreatic Secretory Trypsin Inhibitor in Trypsinogen Activation in Acute Pancreatitis.
- Source :
-
Pancreas [Pancreas] 2020 Apr; Vol. 49 (4), pp. 493-497. - Publication Year :
- 2020
-
Abstract
- The focus of the review is on roles of autophagy and pancreatic secretory trypsin inhibitor (PSTI), an endogenous trypsin inhibitor, in trypsinogen activation in acute pancreatitis. Acute pancreatitis is a disease in which tissues in and around the pancreas are autodigested by pancreatic digestive enzymes. This reaction is triggered by the intrapancreatic activation of trypsinogen. Autophagy causes trypsinogen and cathepsin B, a trypsinogen activator, to colocalize within the autolysosomes. Consequently, if the resultant trypsin activity exceeds the inhibitory activity of PSTI, the pancreatic digestive enzymes are activated, and they cause autodigestion of the acinar cells. Thus, autophagy and PSTI play important roles in the development and suppression of acute pancreatitis, respectively.
- Subjects :
- Acinar Cells pathology
Animals
Cathepsin B metabolism
Disease Models, Animal
Endoplasmic Reticulum Stress
Enzyme Activation
Glycoproteins deficiency
Humans
Lysosomes enzymology
Mice
Mice, Knockout
Molecular Chaperones physiology
Pancreatitis enzymology
Pancreatitis pathology
Prostatic Secretory Proteins
Protein Folding
Proteolysis
Secretory Vesicles enzymology
Transcription Factor CHOP deficiency
Trypsin Inhibitor, Kazal Pancreatic deficiency
Autophagy physiology
Pancreatitis metabolism
Trypsin Inhibitor, Kazal Pancreatic physiology
Trypsinogen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 32282761
- Full Text :
- https://doi.org/10.1097/MPA.0000000000001519