One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus .

One new spirocyclic lactone, terreinlactone C ( 1 ), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde ( 2 ), were discovered from the fungus Aspergillus terreus . The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.[Formula: see text].