A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides.

Authors :: Han BB
Pan YC
Li YM
Guo DS
Chen YX
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 May 21; Vol. 56 (41), pp. 5512-5515.
Publication Year :: 2020
Abstract: We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.

Subjects :: Adenosine Triphosphate chemistry
Arginine chemistry
Arginine metabolism
Calixarenes chemistry
Calixarenes metabolism
Cell Membrane chemistry
Cell Membrane metabolism
Drug Carriers chemistry
Drug Carriers metabolism
HeLa Cells
Humans
Nanoparticles chemistry
Nanoparticles metabolism
Phosphopeptides chemistry
Adenosine Triphosphate metabolism
Phosphopeptides metabolism

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