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Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study.
- Source :
-
Journal of diabetes investigation [J Diabetes Investig] 2020 Nov; Vol. 11 (6), pp. 1643-1650. Date of Electronic Publication: 2020 May 18. - Publication Year :
- 2020
-
Abstract
- Aims/introduction: Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is controversial. We aimed to investigate the association between birthweight and type 2 diabetes mellitus among a general Japanese population.<br />Materials and Methods: Overall 1,135 middle- to old-aged Japanese men and women were enrolled in the Toon Health Study. A 75-g oral glucose tolerance test was used to diagnose type 2 diabetes mellitus, and a questionnaire survey about birthweight was administered. The association between birthweight and the prevalence of type 2 diabetes mellitus in later life of the participants was examined using multivariable logistic regression analysis. Stratified analysis by current body mass index was also carried out.<br />Results: The mean age was 56.5 ± 12.2 years. Type 2 diabetes mellitus was observed in 9.3% of the participants in this study. Compared with the reference group (2,500-3,999 g), the adjusted odds ratio of the low-birthweight group (<2,500 g) for type 2 diabetes mellitus was 2.46 (95% confidence interval 1.48-4.10). The association between the high-birthweight group (≥4000 g) and type 2 diabetes mellitus was not significant after including family history of diabetes in the multivariable model. The odds ratio of the low-birthweight group for type 2 diabetes mellitus was higher in the overweight/obese group than in the non-overweight group.<br />Conclusions: Low birthweight was associated with an increased risk of type 2 diabetes mellitus in a Japanese population, especially in overweight/obese individuals.<br /> (© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Details
- Language :
- English
- ISSN :
- 2040-1124
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of diabetes investigation
- Publication Type :
- Academic Journal
- Accession number :
- 32298536
- Full Text :
- https://doi.org/10.1111/jdi.13274