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MicroRNAs in pulmonary sarcoidosis: A systematic review.
- Source :
-
Respiratory investigation [Respir Investig] 2020 Jul; Vol. 58 (4), pp. 232-238. Date of Electronic Publication: 2020 Apr 15. - Publication Year :
- 2020
-
Abstract
- Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology. Diagnosis of sarcoidosis is made by correlating clinical and radiological features along with the histopathological demonstration of non-necrotizing granulomas in tissue samples. Diagnosis is often challenging as the clinical profile may mimic other granulomatous disorders, including infections, inflammatory diseases, and lymphoid malignancies. Differentiation from tuberculosis is especially crucial in endemic regions where exclusion of mediastinal tuberculosis is necessary before any immunosuppressant treatment can be initiated for symptomatic sarcoidosis. Identification of biomarkers, which can aid in diagnosis as well as prognosis, can be helpful in clinical decision making. MicroRNAs are small non-coding regulatory RNAs that serve as post-transcriptional regulators of gene expression and have been studied as emerging biomarkers in many other respiratory diseases, including lung cancer, asthma, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. In the context of sarcoidosis, miRNA expression has been studied in the lungs, lymph nodes, bronchoalveolar lavage fluid, and peripheral blood mononuclear cells. A comprehensive search of the PubMed database was performed by two authors independently, and relevant studies were retrieved for review. This systematic review summarizes the current information on miRNAs in sarcoidosis, the biological mechanisms involved in CD4 <superscript>+</superscript> T-helper 1 and macrophage polarization, and the use of exhaled breath condensate as an alternative, noninvasive and potential source of miRNAs.<br />Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.<br /> (Copyright © 2020 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Biomarkers analysis
Breath Tests
Bronchoalveolar Lavage Fluid
CD4-Positive T-Lymphocytes
Diagnosis, Differential
Gene Expression
Humans
Leukocytes, Mononuclear
Lung metabolism
Lymph Nodes metabolism
Macrophages
MicroRNAs genetics
T-Lymphocytes, Helper-Inducer
MicroRNAs analysis
Sarcoidosis, Pulmonary diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2212-5353
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Respiratory investigation
- Publication Type :
- Academic Journal
- Accession number :
- 32305227
- Full Text :
- https://doi.org/10.1016/j.resinv.2020.02.008