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[Clinical effect of two different regimens in treatment of acute lymphoblastic leukemia children with bone marrow recurrence].
- Source :
-
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2020 Apr; Vol. 22 (4), pp. 346-349. - Publication Year :
- 2020
-
Abstract
- Objective: To study the short-term effect of two different re-induction regimens in the treatment of acute lymphoblastic leukemia (ALL) children with bone marrow recurrence.<br />Methods: A retrospective analysis was performed for 57 ALL children with bone marrow recurrence. According to their treatment regimen, they were divided into two groups: VMDP (vincristine + mitoxantrone + dexamethasone + PEG-asparaginase; n=42) and VIDP (vincristine + idarubicin + dexamethasone + PEG-asparaginase; n=15). The two groups were compared in terms of complete response rate and incidence rate of adverse reactions.<br />Results: There was no significant difference in complete response rate between the VMDP and VIDP groups (74% vs 73%, P>0.05). All children experienced grade ≥3 hematological adverse events. The VMDP group had a significantly lower chemotherapy-related mortality rate than the VIDP group (P<0.05). There was no significant difference in the incidence rate of infection between the two groups (P>0.05).<br />Conclusions: For ALL children with bone marrow recurrence, both re-induction regimens can achieve a relatively high complete response rate, and VMDP regimen has a lower chemotherapy-related mortality rate and can thus be used as an option for re-induction in ALL children with bone marrow recurrence.
Details
- Language :
- Chinese
- ISSN :
- 1008-8830
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 32312373