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A Survey on Inhibitory Effect of Whole-Body Extraction and Secretions of Lucilia sericata 's Larvae on Leishmania major In vitro .
- Source :
-
Advanced biomedical research [Adv Biomed Res] 2020 Mar 16; Vol. 9, pp. 12. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Background: Leishmaniasis is a skin disease caused by Leishmania parasite. Despite being self-limiting, must be treated. Available drugs have side effects and drug resistance has also been seen.<br />Materials and Methods: Maggot debridement therapy (MDT) is using sterile fly larvae (maggots) of blow flies ( Lucilia sericata ) for the treatment of different types of tissue wounds. Larvae have excreted and secreted substances that have been proved to have antimicrobial effects, in addition to the some other specifications.<br />Results: In this study, the anti-leishmanial effects of extracts and secretions of sterile second- and third-instar larvae of L. sericata on the growth of Leishmania major promastigotes and amastigotes in the J774 macrophages have been evaluated in vitro .<br />Conclusion: The results showed that extracts and secretions had almost the same leishmaniocidal effect on promastigotes and intracellular amastigotes without cytotoxic effect on macrophages.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2020 Advanced Biomedical Research.)
Details
- Language :
- English
- ISSN :
- 2277-9175
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Advanced biomedical research
- Publication Type :
- Academic Journal
- Accession number :
- 32318361
- Full Text :
- https://doi.org/10.4103/abr.abr_56_19