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Differential expression of TIM-3 in circulation and tumor microenvironment of colorectal cancer patients.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Jun; Vol. 215, pp. 108429. Date of Electronic Publication: 2020 Apr 19. - Publication Year :
- 2020
-
Abstract
- T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an inhibitory immune checkpoint, which suppresses anti-tumor immune responses. TIM-3 expression on different immune cells in periphery and tumor microenvironment (TME) of colorectal cancer (CRC) patients has not been fully investigated. We found that TIM-3 was mainly expressed on monocytic myeloid cells (MMCs) and antigen-presenting cells (APCs) in circulation but was mainly expressed on T cells and APCs in the TME. Additionally, TIM-3 <superscript>-</superscript> T cells co-expressed higher levels of PD-1 than TIM-3 <superscript>+</superscript> T cells in normal tissue. In contrast, TIM-3 <superscript>+</superscript> T cells in the TME showed significantly higher PD-1 expression. Interestingly, there was a trend towards increased levels of TIM-3 <superscript>+</superscript> APCs with disease stages; however, levels of TIM-3 <superscript>+</superscript> T cells were decreased with disease stages in the TME. This study shows the differential expression of TIM-3 on different immune cells in circulation and TME of CRC patients, and their associations with disease stages.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Antigen-Presenting Cells metabolism
Biomarkers, Tumor blood
Biomarkers, Tumor metabolism
Cells, Cultured
Humans
Monocytes metabolism
Myeloid Cells metabolism
Programmed Cell Death 1 Receptor metabolism
T-Lymphocytes metabolism
Colorectal Neoplasms blood
Colorectal Neoplasms metabolism
Hepatitis A Virus Cellular Receptor 2 blood
Tumor Microenvironment physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 215
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 32320745
- Full Text :
- https://doi.org/10.1016/j.clim.2020.108429