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Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1.

Authors :
Choi H
Oh C
Hyun J
Yang J
Song MJ
Lee HS
Lee YJ
Source :
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 May 13; Vol. 68 (19), pp. 5349-5355. Date of Electronic Publication: 2020 Apr 29.
Publication Year :
2020

Abstract

Transient receptor potential ankyrin 1 (TRPA1) is a cation channel that plays a critical role in the occurrence and transmission of pain. By screening 393 marine invertebrate extracts for their antagonistic activity against TRPA1, it was found that the extract of the edible sea cucumber Bohadschia vitiensis had a remarkable potency. Bioassay-guided separation of the extract resulted in the isolation of six triterpene glycosides, including a novel analog. All six isolated compounds exhibited high inhibitory potency against TRPA1 (IC <subscript>50</subscript> values ranging from 0.60 to 3.26 μM), which is comparable to that of a previously developed synthetic antagonist (A-967079). The discovery of TRPA1 antagonists, originated from this edible sea cucumber, opens the door for the elaboration of the valuable triterpene scaffold for the development of novel safe analgesics.

Details

Language :
English
ISSN :
1520-5118
Volume :
68
Issue :
19
Database :
MEDLINE
Journal :
Journal of agricultural and food chemistry
Publication Type :
Academic Journal
Accession number :
32324385
Full Text :
https://doi.org/10.1021/acs.jafc.0c00847