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Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2020 Jul 08; Vol. 18 (26), pp. 4916-4921. - Publication Year :
- 2020
-
Abstract
- Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of nBu4NClO4 as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity.
- Subjects :
- Acetylcholinesterase metabolism
Cholinesterase Inhibitors chemical synthesis
Cholinesterase Inhibitors chemistry
Dose-Response Relationship, Drug
Electrodes
Furans chemical synthesis
Furans chemistry
Humans
Molecular Structure
Naphthols chemistry
Organoselenium Compounds chemical synthesis
Organoselenium Compounds chemistry
Phenols chemistry
Cholinesterase Inhibitors pharmacology
Electrochemical Techniques
Furans pharmacology
Naphthols pharmacology
Organoselenium Compounds pharmacology
Phenols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 18
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32353091
- Full Text :
- https://doi.org/10.1039/d0ob00629g