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Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2020 Nov; Vol. 40 (11), pp. 1625-1633. Date of Electronic Publication: 2020 May 04. - Publication Year :
- 2020
-
Abstract
- Introduction: Pulmonary hypertension (PH) is a common comorbidity of cardiopulmonary disease. Endostatin, an inhibitor of angiogenesis, is elevated in neonates with lung disease. ST2 is a heart failure biomarker correlated with PH in adults. We hypothesized that these biomarkers may be useful in diagnosing PH and categorizing its severity in infants.<br />Methods: Endostatin, ST2, and NT-proBNP plasma concentrations from 26 infants with PH and 21 control infants without PH were correlated with echocardiographic and clinical features using regression models over time.<br />Results: Endostatin, ST2, and NT-proBNP concentrations were elevated in PH participants versus controls (p < 0.0001). Endostatin was associated with right ventricular dysfunction (p = 0.014), septal flattening (p = 0.047), and pericardial effusion (p < 0.0001). ST2 concentrations predicted right to left patent ductus arteriosus flow (p = 0.009). NT-proBNP was not associated with PH features.<br />Conclusions: Endostatin and ST2 concentrations were associated with echocardiographic markers of worse PH in infants and may be better predictors than existing clinical standards.
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 40
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 32366869
- Full Text :
- https://doi.org/10.1038/s41372-020-0671-8