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Acute myocardial infarctions and stroke triggered by laboratory-confirmed respiratory infections in Denmark, 2010 to 2016.
- Source :
-
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2020 Apr; Vol. 25 (17). - Publication Year :
- 2020
-
Abstract
- BackgroundSeveral studies have investigated a possible association between respiratory infection and acute myocardial infarction (MI). As both influenza and pneumococcal infections are vaccine preventable, understanding the populations affected by virus-induced cardiovascular complications is important to guide public health and clinical practice.AimThis observational study aimed to quantify the association between laboratory-confirmed respiratory bacteria or virus infections and risk of first MI or stroke, by using self-controlled case series (SCCS) analysis of anonymised linked electronic Danish health records.MethodsThe SCCS method was used to determine the relative incidence of the first event of MI and stroke occurring within 28 days after laboratory-confirmed respiratory infections compared with the baseline time period.ResultsIn the age and season adjusted analyses for first acute MI, the incidence ratios (IR) of a MI event occurring during the risk period were significantly elevated following a Streptococcus pneumoniae infection with values of 20.1, 11.0 and 4.9 during 1-3, 4-7 and 8-14 days, respectively and following respiratory virus infection with values of 15.2, 4.5 and 4.4 during 1-3, 8-14 and 15-28 days, respectively. The significantly elevated IRs for stroke following an S. pneumoniae infection were 25.5 and 6.3 during 1-3 and 8-14 days, respectively and following respiratory virus infection 8.3, 7.8 and 6.2 during 1-3, 4-7 and 8-14 days, respectively.ConclusionThis study suggested a significant cardiovascular event triggering effect following infection with S. pneumoniae and respiratory viruses (mainly influenza), indicating the importance of protection against vaccine-preventable respiratory infections.
- Subjects :
- Adult
Aged
Aged, 80 and over
Denmark epidemiology
Female
Humans
Incidence
Influenza, Human epidemiology
Male
Middle Aged
Myocardial Infarction epidemiology
Pneumococcal Infections epidemiology
Respiratory Tract Infections epidemiology
Respiratory Tract Infections microbiology
Respiratory Tract Infections virology
Stroke epidemiology
Influenza, Human complications
Myocardial Infarction etiology
Pneumococcal Infections complications
Respiratory Tract Infections complications
Stroke etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1560-7917
- Volume :
- 25
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 32372757
- Full Text :
- https://doi.org/10.2807/1560-7917.ES.2020.25.17.1900199