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Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease.
- Source :
-
Journal of medicinal food [J Med Food] 2020 Jul; Vol. 23 (7), pp. 760-771. Date of Electronic Publication: 2020 May 07. - Publication Year :
- 2020
-
Abstract
- It is well known that nonalcoholic fatty liver disease (NAFLD) is a common disease worldwide because of unhealthy changes in dietary habits. In this study, we determined the effects of Tenebrio molitor Linnaeus, 1758 extract (TML) and Allomyrina dichotoma Linnaeus, 1771 larvae extract (ADL) in cellular and animal models. In vitro , TML and ADL treatments did not cause cytotoxicity, but attenuated the accumulation of lipid in HepG2 cells induced by free fatty acids. In vivo , mice were orally treated with TML and ADL for 10 weeks during high-fat diet feeding. TML and ADL administration significantly reduced the weight of body, liver tissue, and adipose tissue. Serum lipid profiles, hepatic functional parameters, and glucose levels were ameliorated by TML and ADL. Moreover, TML and ADL suppressed increased lipogenesis and inflammation-related makers, and improved antioxidant enzyme activity. In liver tissue, the decreased lipid accumulation by administration of TML and ADL was observed using Oil Red O and Hematoxylin and Eosin staining. Therefore, we suggest that TML and ADL may be having a therapeutic potential and is used to develop a therapeutic agent for NAFLD.
Details
- Language :
- English
- ISSN :
- 1557-7600
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of medicinal food
- Publication Type :
- Academic Journal
- Accession number :
- 32380876
- Full Text :
- https://doi.org/10.1089/jmf.2019.4536