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The expression of urokinase-type plasminogen activator system in upper tract urothelial carcinoma and its prognostic value after radical nephroureterectomy.
- Source :
-
Urologic oncology [Urol Oncol] 2020 Aug; Vol. 38 (8), pp. 685.e17-685.e25. Date of Electronic Publication: 2020 May 04. - Publication Year :
- 2020
-
Abstract
- Background: To evaluate the expression pattern and prognostic role of the urokinase-type plasminogen activator (uPA) system in patients who underwent radical nephroureterectomy (RNU) for nonmetastatic upper tract urothelial carcinoma (UTUC).<br />Methods: A total of 732 patients who were treated with RNU for clinically nonmetastatic UTUC comprised our analytical cohort. Immunohistochemical staining of uPA, uPA receptor (uPAR) and uPA inhibitor (PAI-1) was performed using Murine IgG1 monoclonal antibodies. Outcomes of interest were recurrence-free survival, cancer-specific survival, and overall survival.<br />Results: The median age of the patients was 69.8 years and 56.6% of them were males. Overall, overexpression of uPA, uPAR, and PAI-1 was observed in 292 (39.9%), 346 (47.3%), and 345 (47.1%) patients, respectively. The uPA system components showed a statistically significant association with adverse clinicopathologic features such as lymphovascular invasion, multifocality, sessile tumors, and advanced pathologic stage (P < 0.01). On multivariable models, higher pathologic tumor stage, multifocality, and lymph node involvement were associated with RFS, OS, and CSS, but not the overexpression of uPA, uPAR, or PAR-1. In patients with organ-confined disease (≤pT2N0), however, uPA was significantly associated with RFS (hazard ratio [HR]: 2.04, 95% confidence interval [CI]: 1.21-3.43), OS (HR: 1.59, 95% CI:1.08-2.24) and CSS (HR: 2.55, 95% CI:1.44-4.52). uPA improved the predictive accuracy of a standard post-RNU model for all 3 endpoints, in organ-confined disease, by a prognostically significant margin.<br />Conclusions: Overexpression of uPA system components was associated with adverse clinicopathologic characteristics and survival outcomes on the univariable, but not multivariable analyses. uPA expression was an independent predictor of survival outcomes in patients with organ-confined disease. While the clinical value of the uPA system remains limited in this cohort, further studies are needed to identify a marker or constellation of markers of high predictive value to help in counseling and treatment planning of UTUC patients.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Aged
Carcinoma, Transitional Cell mortality
Disease-Free Survival
Female
Humans
Kidney Neoplasms mortality
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate
Ureteral Neoplasms mortality
Carcinoma, Transitional Cell metabolism
Carcinoma, Transitional Cell surgery
Kidney Neoplasms metabolism
Kidney Neoplasms surgery
Nephroureterectomy methods
Ureteral Neoplasms metabolism
Ureteral Neoplasms surgery
Urokinase-Type Plasminogen Activator biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2496
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Urologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32381392
- Full Text :
- https://doi.org/10.1016/j.urolonc.2020.03.030