Back to Search
Start Over
Covid-19, induced activation of hemostasis, and immune reactions: Can an auto-immune reaction contribute to the delayed severe complications observed in some patients?
- Source :
-
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2020 Jun; Vol. 59 (3), pp. 102804. Date of Electronic Publication: 2020 May 03. - Publication Year :
- 2020
-
Abstract
- Covid-19 is characterized by weak symptoms in most affected patients whilst severe clinical complications, with frequent fatal issues, occur in others. Disease severity is associated with age and comorbidities. Understanding of viral infectious mechanisms, and antibody immune response, can help to better control disease progression. SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication. This report hypothesizes the possible implication of an autoimmune response, induced by generation of allo- or autoantibodies to ACE-2, or to its complexes with viral spike protein. This could contribute to some delayed severe complications occurring in affected patients. We also propose a strategy for investigating this eventuality.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Angiotensin-Converting Enzyme 2
Antibody Specificity
COVID-19
Coronavirus Infections complications
Coronavirus Infections immunology
Cytokine Release Syndrome etiology
Cytokine Release Syndrome immunology
Disease Progression
Disseminated Intravascular Coagulation etiology
Humans
Pandemics
Peptidyl-Dipeptidase A blood
Peptidyl-Dipeptidase A physiology
Pneumonia, Viral complications
Pneumonia, Viral immunology
SARS-CoV-2
Serine Endopeptidases physiology
Severity of Illness Index
Spike Glycoprotein, Coronavirus immunology
Spike Glycoprotein, Coronavirus metabolism
Thrombophilia blood
Thrombophilia immunology
Time Factors
Antibodies, Viral immunology
Autoantibodies immunology
Autoimmunity
Betacoronavirus immunology
Blood Coagulation
Coronavirus Infections blood
Isoantibodies immunology
Peptidyl-Dipeptidase A immunology
Pneumonia, Viral blood
Renin-Angiotensin System physiology
Thrombophilia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0502
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Publication Type :
- Academic Journal
- Accession number :
- 32387238
- Full Text :
- https://doi.org/10.1016/j.transci.2020.102804