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Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC).
- Source :
-
Aging [Aging (Albany NY)] 2020 May 14; Vol. 12 (9), pp. 8484-8505. Date of Electronic Publication: 2020 May 14. - Publication Year :
- 2020
-
Abstract
- Clear cell renal cell carcinoma (ccRCC) is the most common subtype among kidney cancer, which has poor prognosis. The aim of this study was to screen out novel prognostic biomarkers and therapeutic targets for immunotherapy, and some novel molecule drugs for ccRCC treatment. Immune scores ranged from -1109.36 to 2920.81 and stromal scores ranged from -1530.11 to 1955.39 were firstly calculated by applying ESTIMATE algorithm. Then 17 DEGs associated with immune score and stromal score were further identified. 6 candidate hub genes were screened out by performing overall survival (OS) and disease-free survival analyses based on TCGA-KIRC data, one of which including TGFBI was further regarded as hub gene associated with prognosis by calculating the R <superscript>2</superscript> (R <superscript>2</superscript> = 0.011, P = 0.018) and AUC (AUC = 0.874). The prognostic value of TGFBI was validated by performing OS, CSS, and PFS analyses based on GSE29609 and E-MTAB-3267. CMap analysis suggested that 3 molecule drugs might be novel choice for ccRCC treatment. Further analysis demonstrated that CNVs of TGFBI was associated with OS of patients with ccRCC. TGFBI expression was also correlated with histologic grade, pathologic stage, and immune infiltration level, significantly. TGFBI was the most relevant gene with OS among the candidate hub genes, which might be novel DNA methylation biomarkers for ccRCC. In conclusion, our findings indicated that TGFBI was correlated with prognosis of patients with ccRCC, which might be novel prognostic biomarkers, and targets for immunotherapy in ccRCC. Three small molecule drugs were also identified, which showed strong potential for ccRCC treatment.
- Subjects :
- Biomarkers, Tumor immunology
Carcinoma, Renal Cell genetics
Carcinoma, Renal Cell pathology
DNA Methylation
Disease-Free Survival
Extracellular Matrix Proteins immunology
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic genetics
Humans
Kidney Neoplasms genetics
Kidney Neoplasms pathology
Male
Prognosis
Transforming Growth Factor beta immunology
Biomarkers, Tumor genetics
Carcinoma, Renal Cell immunology
Extracellular Matrix Proteins genetics
Gene Regulatory Networks immunology
Kidney Neoplasms immunology
Transforming Growth Factor beta genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 32406866
- Full Text :
- https://doi.org/10.18632/aging.103153