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Plasma cytokine profiles in very preterm infants with late-onset sepsis.
- Source :
-
PloS one [PLoS One] 2020 May 14; Vol. 15 (5), pp. e0232933. Date of Electronic Publication: 2020 May 14 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Introduction: Deficiencies in innate immune responses may contribute to the increased susceptibility to infection in preterm infants. In vivo cytokine profiles in response to sepsis in very preterm infants are not fully understood.<br />Aims: To characterise plasma pro- and anti-inflammatory cytokine concentrations and pre-defined ratios in very preterm infants with late-onset sepsis (LOS).<br />Methods: In this observational study, peripheral blood samples were collected at the time of evaluation for suspected LOS from 31 preterm infants (<30 weeks gestational age). Plasma cytokine concentrations were determined by 12-plex immunoassay.<br />Results: IL-10, IFN-γ, IL-12p70, IP-10, IL-6 and CCL2 were elevated in the majority infants with LOS (n = 12) compared to those without LOS (n = 19). There was no difference in TNF-α, IL-1β, IL-17AF, IL-8 and IL-15 concentrations between groups. IL-10/TNF-α ratios were increased, while CCL2/IL-10 and IL-12p70/IL-10 ratios were decreased in infants with LOS compared to those without.<br />Conclusion: Very preterm infants have a marked innate inflammatory response at the time of LOS. The increase in IL-10/TNF-α ratio may indicate early immune hypo-responsiveness. Longitudinal studies with a larger number of participants are required to understand immune responses and clinical outcomes following LOS in preterm infants.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Australia epidemiology
Case-Control Studies
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature blood
Infant, Premature, Diseases blood
Infant, Premature, Diseases epidemiology
Infant, Premature, Diseases immunology
Infant, Very Low Birth Weight blood
Inflammation blood
Inflammation epidemiology
Inflammation immunology
Male
Prospective Studies
Sepsis blood
Sepsis epidemiology
Sepsis immunology
Biomarkers blood
Cytokines blood
Infant, Premature immunology
Infant, Premature, Diseases diagnosis
Infant, Very Low Birth Weight immunology
Inflammation diagnosis
Sepsis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 32407417
- Full Text :
- https://doi.org/10.1371/journal.pone.0232933