Back to Search
Start Over
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 Nov 19; Vol. 71 (16), pp. 2272-2275. - Publication Year :
- 2020
-
Abstract
- Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Aged
COVID-19 blood
Cytokines immunology
Female
Humans
Inflammation complications
Inflammation immunology
Intensive Care Units statistics & numerical data
Italy
Lymphocyte Activation immunology
Male
Middle Aged
SARS-CoV-2
COVID-19 immunology
Inflammation blood
Killer Cells, Natural immunology
Perforin immunology
T-Lymphocytes, Cytotoxic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 71
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 32407466
- Full Text :
- https://doi.org/10.1093/cid/ciaa577