Cytochalasans from endophytic fungus Diaporthe sp. SC-J0138.

Authors :: Yang X
Wu P
Xue J
Li H
Wei X
Source :: Fitoterapia [Fitoterapia] 2020 Sep; Vol. 145, pp. 104611. Date of Electronic Publication: 2020 May 11.
Publication Year :: 2020
Abstract: Five new cytochalasans, diaporthichalasins D-H (1-5), along with five known cytochalasans (6-10) were isolated from solid cultures of the endophytic fungus Diaporthe sp. SC-J0138 isolated from the leaves of Cyclosorus parasiticus. Their structures were elucidated by analysis of spectroscopic data and theoretical calculations of electronic circular dichroism spectra. Compounds 1 and 5 showed noticeable cytotoxicity against human carcinoma A549, HeLa, and HepG2 cells. The structure-activity relationships in cytotoxicity were discussed for this group of compounds.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)