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Cytochalasans from endophytic fungus Diaporthe sp. SC-J0138.
- Source :
-
Fitoterapia [Fitoterapia] 2020 Sep; Vol. 145, pp. 104611. Date of Electronic Publication: 2020 May 11. - Publication Year :
- 2020
-
Abstract
- Five new cytochalasans, diaporthichalasins D-H (1-5), along with five known cytochalasans (6-10) were isolated from solid cultures of the endophytic fungus Diaporthe sp. SC-J0138 isolated from the leaves of Cyclosorus parasiticus. Their structures were elucidated by analysis of spectroscopic data and theoretical calculations of electronic circular dichroism spectra. Compounds 1 and 5 showed noticeable cytotoxicity against human carcinoma A549, HeLa, and HepG2 cells. The structure-activity relationships in cytotoxicity were discussed for this group of compounds.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- A549 Cells
Antineoplastic Agents isolation & purification
Biological Products isolation & purification
China
Cytochalasins isolation & purification
Endophytes chemistry
HeLa Cells
Hep G2 Cells
Humans
MCF-7 Cells
Molecular Structure
Plant Leaves microbiology
Structure-Activity Relationship
Tracheophyta microbiology
Antineoplastic Agents pharmacology
Ascomycota chemistry
Biological Products pharmacology
Cytochalasins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 145
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 32437736
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104611