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Collection and Separation of Fleroxacin and Ciprofloxacin in Ultrasound-Assisted Ionic Liquid Salting-Out Microextraction System.
- Source :
-
Journal of chromatographic science [J Chromatogr Sci] 2020 Jun 05; Vol. 58 (6), pp. 576-584. - Publication Year :
- 2020
-
Abstract
- An ultrasound-assisted ionic liquid (IL) salting-out microextraction system was developed and applied for the extraction of quinolone antibiotics from urine. A precipitate was formed from the salt and IL, and it acted as the sorbent for the analytes. The precipitate containing the analyte was separated by filtration, redissolved, and the solution then was evaporated. The resulting extract was redissolved for high-performance liquid chromatographic analysis. Several parameters, including type and volume of IL, the type and amount of salts, sample pH, temperature and extraction time were optimized. Under the optimal experimental conditions, the limits of detection for fleroxacin and ciprofloxacin were 3.12 and 4.97 μg L-1, respectively. When the present method was applied to real urine sample analysis, the analyte recoveries ranged from 82.3 to 106.8%. This ultrasound-assisted IL salting-out microextraction system had the characteristics of high recoveries, shorter separation time and easy-to-perform collection procedure, which yielded the method to have potential for wide application.<br /> (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Animals
Chromatography, High Pressure Liquid methods
Ciprofloxacin analysis
Ciprofloxacin chemistry
Fleroxacin analysis
Fleroxacin chemistry
Humans
Ionic Liquids chemistry
Limit of Detection
Linear Models
Rabbits
Reproducibility of Results
Rivers chemistry
Sodium Chloride chemistry
Temperature
Ciprofloxacin isolation & purification
Ciprofloxacin urine
Fleroxacin isolation & purification
Fleroxacin urine
Liquid Phase Microextraction methods
Sonication methods
Subjects
Details
- Language :
- English
- ISSN :
- 1945-239X
- Volume :
- 58
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of chromatographic science
- Publication Type :
- Academic Journal
- Accession number :
- 32448888
- Full Text :
- https://doi.org/10.1093/chromsci/bmaa021