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Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cells.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Aug 17; Vol. 59 (34), pp. 14584-14592. Date of Electronic Publication: 2020 Jul 09. - Publication Year :
- 2020
-
Abstract
- Herein, we report on the design of a programmable DNA ribbon using long-chain DNA molecules with a user-defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high-density DNA crown carrying a cancer-cell-targeting DNA aptamer, a fluorescent tag for location tracking, and a cell-killing drug. This composite material can be efficiently internalized by cancer cells and its cellular location can be tracked by fluorescence imaging. The system offers several attractive characteristics, including simple design, tunable DNA crown, high drug-loading capacity, selective cell targeting, and pH-sensitive drug release. These features make such a material a promising therapeutic agent.<br /> (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antineoplastic Agents therapeutic use
Cell Line, Tumor
Doxorubicin administration & dosage
Doxorubicin therapeutic use
Humans
Microscopy, Atomic Force
Antineoplastic Agents administration & dosage
DNA chemistry
Drug Delivery Systems
Gold chemistry
Metal Nanoparticles chemistry
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 59
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 32470152
- Full Text :
- https://doi.org/10.1002/anie.202005624