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A Highly Selective and Sensitive Chemiluminescent Probe for Real-Time Monitoring of Hydrogen Peroxide in Cells and Animals.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Aug 17; Vol. 59 (34), pp. 14326-14330. Date of Electronic Publication: 2020 Jul 01. - Publication Year :
- 2020
-
Abstract
- Selective and sensitive molecular probes for hydrogen peroxide (H <subscript>2</subscript> O <subscript>2</subscript> ), which plays diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the physiological and pathological effects of H <subscript>2</subscript> O <subscript>2</subscript> . A lack of reliable tools for in vivo imaging has hampered the development of H <subscript>2</subscript> O <subscript>2</subscript> mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H <subscript>2</subscript> O <subscript>2</subscript> -CL-510 was developed as a highly selective and sensitive probe for detection of H <subscript>2</subscript> O <subscript>2</subscript> both in vitro and in vivo. A rapid 430-fold enhancement of chemiluminescence was triggered directly by H <subscript>2</subscript> O <subscript>2</subscript> without any laser excitation. Arsenic trioxide induced oxidative damage in leukemia was successfully detected. In particular, cerebral ischemia-reperfusion injury-induced H <subscript>2</subscript> O <subscript>2</subscript> fluxes were visualized in rat brains using H <subscript>2</subscript> O <subscript>2</subscript> -CL-510, providing a new chemical tool for real-time monitoring of H <subscript>2</subscript> O <subscript>2</subscript> dynamics in living animals.<br /> (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 59
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 32472602
- Full Text :
- https://doi.org/10.1002/anie.202005429