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Association between lipid fractions and age of first myocardial infarction.
- Source :
-
Scandinavian cardiovascular journal : SCJ [Scand Cardiovasc J] 2020 Dec; Vol. 54 (6), pp. 346-351. Date of Electronic Publication: 2020 Jun 02. - Publication Year :
- 2020
-
Abstract
- Objective: Dyslipidemia is a major cause of early coronary heart disease (CHD). Low-density-lipoprotein cholesterol (LDL-C), remnant cholesterol (remnant-C) and high-density lipoprotein cholesterol (HDL-C) have all been shown to be associated with risk of CHD. We aimed to compare the association of these lipid fractions with age at first myocardial infarction(MI). Design . Multicenter study of consecutive patients hospitalized with a first MI. Linear regression models were used to assess the independent association of LDL-C, remnant-C and HDL-C with age at first MI. Results . The study included 1744 patients. In univariate analyses, LDL-C, remnant-C, and HDL-C were all significantly associated with age at first MI. However, in multivariate analyses only LDL-C [-2.5 years (95%CI: -3.1 to -1.8) per 1 SD increase] and to a lesser extent remnant-C [-0.9 years (95% CI: -1.5 to -0.3)] continued to be associated with age of MI, while HDL-C [0.5 years (95%CI: -0.2 to 1.2)] was not. Conclusions . LDL-C is the lipid fraction strongest associated with younger age of presentation of first MI. These results support the importance of controlling and treating LDL-C in prevention of premature MI.
- Subjects :
- Age of Onset
Aged
Aged, 80 and over
Cholesterol blood
Cholesterol, HDL blood
Computed Tomography Angiography
Coronary Angiography
Coronary Artery Disease diagnostic imaging
Denmark epidemiology
Dyslipidemias diagnosis
Dyslipidemias epidemiology
Female
Heart Disease Risk Factors
Humans
Lipoproteins blood
Male
Middle Aged
Myocardial Infarction diagnostic imaging
Prognosis
Retrospective Studies
Risk Assessment
Triglycerides blood
Cholesterol, LDL blood
Coronary Artery Disease epidemiology
Dyslipidemias blood
Myocardial Infarction epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2006
- Volume :
- 54
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Scandinavian cardiovascular journal : SCJ
- Publication Type :
- Academic Journal
- Accession number :
- 32483990
- Full Text :
- https://doi.org/10.1080/14017431.2020.1770850