Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha.

Authors :: Liu W
Song Z
Wang H
Yang X
Joubert E
Zhang J
Li S
Tuerhong M
Abudukeremu M
Jin J
Xu J
Lee D
Guo Y
Source :: Bioorganic chemistry [Bioorg Chem] 2020 Aug; Vol. 101, pp. 103966. Date of Electronic Publication: 2020 May 22.
Publication Year :: 2020
Abstract: A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC <subscript>50</subscript> values < 40 μM). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.<br />Competing Interests: Declaration of Competing Interest The authors of the present manuscript have declared that no competing interests exist.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)