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Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation.
- Source :
-
Nature communications [Nat Commun] 2020 Jun 12; Vol. 11 (1), pp. 2988. Date of Electronic Publication: 2020 Jun 12. - Publication Year :
- 2020
-
Abstract
- Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melanocytes into signaling cues promoting their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we show that caveolae are asymmetrically distributed in melanocytes and particularly abundant at the melanocyte-keratinocyte interface in epidermis. Caveolae in melanocytes are modulated by ultraviolet radiations and keratinocytes-released factors, like miRNAs. Preventing caveolae formation in melanocytes increases melanin pigment synthesis through upregulation of cAMP signaling and decreases cell protrusions, cell-cell contacts, pigment transfer and epidermis pigmentation. Altogether, we identify that caveolae serve as molecular hubs that couple signaling outputs from keratinocytes to mechanical plasticity of pigment cells. The coordination of intercellular communication and contacts by caveolae is thus crucial to skin pigmentation and tissue homeostasis.
- Subjects :
- Caveolin 1 metabolism
Cell Communication physiology
Cell Communication radiation effects
Cells, Cultured
Coculture Techniques
Epidermal Cells metabolism
Epidermis metabolism
Epidermis ultrastructure
HeLa Cells
Humans
Keratinocytes cytology
Melanocytes cytology
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Signal Transduction physiology
Signal Transduction radiation effects
Skin cytology
Skin ultrastructure
Ultraviolet Rays
Caveolae metabolism
Keratinocytes metabolism
Melanocytes metabolism
Skin metabolism
Skin Pigmentation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 32532976
- Full Text :
- https://doi.org/10.1038/s41467-020-16738-z