Back to Search
Start Over
Spondweni virus causes fetal harm in Ifnar1 -/- mice and is transmitted by Aedes aegypti mosquitoes.
- Source :
-
Virology [Virology] 2020 Aug; Vol. 547, pp. 35-46. Date of Electronic Publication: 2020 May 24. - Publication Year :
- 2020
-
Abstract
- Spondweni virus (SPONV) is the most closely related known flavivirus to Zika virus (ZIKV). Its pathogenic potential and vector specificity have not been well defined. SPONV has been found predominantly in Africa, but was recently detected in a pool of Culex quinquefasciatus mosquitoes in Haiti. Here we show that SPONV can cause significant fetal harm, including demise, comparable to ZIKV, in a mouse model of vertical transmission. Following maternal inoculation, we detected infectious SPONV in placentas and fetuses, along with significant fetal and placental histopathology, together suggesting vertical transmission. To test vector competence, we exposed Aedes aegypti and Culex quinquefasciatus mosquitoes to SPONV-infected bloodmeals. Aedes aegypti could efficiently transmit SPONV, whereas Culex quinquefasciatus could not. Our results suggest that SPONV has the same features that made ZIKV a public health risk.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aedes physiology
Animals
Disease Models, Animal
Female
Flavivirus genetics
Flavivirus Infections genetics
Flavivirus Infections metabolism
Flavivirus Infections mortality
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Mosquito Vectors physiology
Receptor, Interferon alpha-beta deficiency
Aedes virology
Flavivirus physiology
Flavivirus Infections virology
Mosquito Vectors virology
Receptor, Interferon alpha-beta genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 547
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 32560903
- Full Text :
- https://doi.org/10.1016/j.virol.2020.05.005