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Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control.
- Source :
-
Annual review of biochemistry [Annu Rev Biochem] 2020 Jun 20; Vol. 89, pp. 417-442. - Publication Year :
- 2020
-
Abstract
- Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.
- Subjects :
- Escherichia coli metabolism
Humans
Models, Molecular
Poly A chemistry
Poly A genetics
Poly A metabolism
Proteasome Endopeptidase Complex genetics
Protein Binding
Protein Interaction Domains and Motifs
Protein Structure, Secondary
Proteolysis
RNA Splicing
RNA Stability
Ribosomes metabolism
Ribosomes ultrastructure
Ubiquitin-Protein Ligases chemistry
Ubiquitin-Protein Ligases genetics
Ubiquitin-Protein Ligases metabolism
Ubiquitination
Escherichia coli genetics
Proteasome Endopeptidase Complex metabolism
Protein Biosynthesis
Protein Processing, Post-Translational
Ribosomes genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1545-4509
- Volume :
- 89
- Database :
- MEDLINE
- Journal :
- Annual review of biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32569528
- Full Text :
- https://doi.org/10.1146/annurev-biochem-013118-110729