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Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Jul 22; Vol. 12 (29), pp. 32301-32311. Date of Electronic Publication: 2020 Jul 07. - Publication Year :
- 2020
-
Abstract
- A fever-mimic response capable of recruiting reprogrammed macrophages holds great potential in the engineering of the tumor microenvironment (TME). Low-temperature photothermal therapy (LT-PTT) can maintain tumors at a fever-like temperature (<45 °C) temporarily; however, it still faces several challenges in efficient regulation of TME because of reciprocal cross-talk between the bypass pathways. Here, we report a synergistic engineering of TME through an enhanced activation of a fever-mimic response based on both LT-PTT and tumor vascular normalization. Such engineering is achieved by a fever-inducible lipid nanocomposite (GNR-T/CM-L), which produces mild heat (∼43 °C) and sequentially releases multicomponents to cooperatively upregulate interferon-gamma under NIR irradiation, forming a bidirectionally closed loop for downstream M1 tumor-associated macrophage polarization and promoting the inhibition of the tumor growth. In proof-of-concept studies, GNR-T/CM-L demonstrated efficient tumor ablation in breast tumor xenograft-bearing mice and significantly prolonged their survival period. It paves an avenue to precisely reprogram TME for efficient cancer therapy through synergistic pathways of creating fever-like responses in the tumor.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Female
Humans
Infrared Rays
Lipids chemistry
MCF-7 Cells
Mammary Neoplasms, Experimental drug therapy
Mice
Mice, Nude
Optical Imaging
Particle Size
Photosensitizing Agents chemistry
Photothermal Therapy
Surface Properties
Tumor Microenvironment drug effects
Antineoplastic Agents pharmacology
Hyperthermia, Induced
Lipids pharmacology
Nanocomposites chemistry
Photosensitizing Agents pharmacology
Temperature
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 12
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 32575984
- Full Text :
- https://doi.org/10.1021/acsami.0c06949