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Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity.
- Source :
-
Current topics in medicinal chemistry [Curr Top Med Chem] 2020; Vol. 20 (21), pp. 1916-1937. - Publication Year :
- 2020
-
Abstract
- Cancer, which has been cursed for human beings for long time is considered as one of the leading causes of morbidity and mortality across the world. In spite of different types of treatments available, chemotherapy is still deemed as a favored treatment for the cancer. Unfortunately, many currently accessible anticancer agents have developed multidrug resistance along with fatal adverse effects. Therefore, intensive efforts have been made to seek for new active drugs with improved anticancer efficacy and reduced adverse effects. In recent years, the emergence of heterocyclic ring-containing anticancer agents has gained a great deal of attention among medicinal chemists. 1,3- oxazole is a versatile heterocyclic compound, and its derivatives possess broad-spectrum pharmacological properties, including anticancer activity against both drug-susceptible, drug-resistant and even multidrug-resistant cancer cell lines through multiple mechanisms. Thus, the 1,3-oxazole moiety is a useful template for the development of novel anticancer agents. This review will provide a comprehensive overview of the recent advances on 1,3-oxazole derivatives with potential therapeutic applications as anticancer agents, focus on the chemical structures, anticancer activity, and mechanisms of action.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Proliferation drug effects
Cell Survival drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Oxazoles chemical synthesis
Oxazoles chemistry
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Oxazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4294
- Volume :
- 20
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Current topics in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32579505
- Full Text :
- https://doi.org/10.2174/1568026620666200624161151