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Chitosan dressings containing inorganic additives and levofloxacin as potential wound care products with enhanced hemostatic properties.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 693-703. Date of Electronic Publication: 2020 Jun 23. - Publication Year :
- 2020
-
Abstract
- Despite the progress in the development of hemostatic products, efficient treatment solutions to control hemorrhage upon wounding are still necessary. Chitosan (CS) is a natural hydrogel-forming polysaccharide, easy to modify for specific applications. Inorganic compounds in turn possess documented hemostatic properties. In this study, innovative hemostatic products based on CS, containing the inorganic additives aluminum chloride, aluminum sulfate hydrate or iron(III) sulfate and the antibiotic Levofloxacin were prepared, and their potential use as hemostatic materials was investigated. Structural characteristics, physical state and drug loading/release properties were examined. Strong interactions developed between CS and the additives, the pore size in the resulting products was affected, swelling increased up to 2500% and the stability of the wound dressings improved. The crystallinity of Levofloxacin reduced, and its release was immediate. The materials showed biocompatibility upon contact with cultured keratinocytes, hemocompatibility and hemostatic efficacy in vitro and in vivo.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Anti-Bacterial Agents pharmacology
Blood Coagulation
Cells, Cultured
Humans
Keratinocytes
Mice, Inbred C57BL
Porosity
Bandages
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Chitosan chemistry
Chitosan pharmacology
Ferric Compounds chemistry
Ferric Compounds pharmacology
Hemostatics chemistry
Hemostatics pharmacology
Hydrogels chemistry
Hydrogels pharmacology
Levofloxacin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 162
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32585270
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.06.187