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Bone marrow contribution to the heart from development to adulthood.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2021 Apr; Vol. 112, pp. 16-26. Date of Electronic Publication: 2020 Jun 23. - Publication Year :
- 2021
-
Abstract
- Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Bone Marrow Cells physiology
Cell Differentiation genetics
Cell Lineage genetics
Cell Lineage physiology
Endothelial Cells physiology
Heart physiopathology
Heart Diseases genetics
Heart Diseases physiopathology
Humans
Bone Marrow physiology
Heart growth & development
Hematopoietic Stem Cells physiology
Regeneration physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 112
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 32591270
- Full Text :
- https://doi.org/10.1016/j.semcdb.2020.06.008